Which medication is known to interact with grapefruit?

Verapamil is known to interact with grapefruit due to the effect of grapefruit juice on cytochrome P450 enzymes, particularly CYP3A4. This enzyme plays a critical role in the metabolism of various medications, including verapamil. When grapefruit or grapefruit juice is consumed, it can inhibit the activity of CYP3A4, leading to increased plasma concentrations of verapamil. This may result in enhanced effects and a higher risk of side effects, such as hypotension or bradycardia.

Other medications listed, such as ibuprofen, aspirin, and amoxicillin, do not exhibit this type of interaction with grapefruit. They are primarily metabolized by different pathways that are not significantly affected by the compounds found in grapefruit, making them safer options in this regard. Understanding the interaction between certain medications and grapefruit is crucial for preventing potential adverse effects and ensuring safe medication management.